Across TCGA pan-cancer cohorts, MIRLET7C RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MIRLET7C’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where MIRLET7C RNA is repressed in tumor relative to normal tissue. In most cancer types MIRLET7C is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, BRCA, and UCEC are the cancer types where MIRLET7C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIRLET7C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.555	<.001	9	view →
BRCA	Female	All	−0.311	<.001	6	view →
UCEC	All	All	−0.440	.007	2	view →
THCA	All	All	−0.270	.006	2	view →
KIRP	All	All	−0.247	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: MIRLET7C RNA expression & survival · all MIRLET7C data types