Across TCGA pan-cancer cohorts, MIR99AHG RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of MIR99AHG’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MIR99AHG RNA is repressed in tumor relative to normal tissue. In most cancer types MIR99AHG is over-expressed in tumor, although a few such as KIRC and HNSC show the opposite, repressed pattern.

KIRC, HNSC, and KICH are the cancer types where MIR99AHG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR99AHG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.065	<.001	12	view →
HNSC	Male	All	−0.818	<.001	12	view →
KICH	Female	II,III,IV	−1.977	<.001	10	view →
KIRP	All	III,IV	−0.960	<.001	9	view →
THCA	All	All	−0.505	<.001	9	view →
UCEC	All	All	−2.263	<.001	8	view →
LUSC	Male	III,IV	−1.467	<.001	8	view →
LUAD	Female	III,IV	−1.223	<.001	7	view →
BRCA	All	III,IV	−1.676	<.001	6	view →
BLCA	All	IV	−1.345	.002	6	view →
STAD	All	All	−0.700	<.001	5	view →
LIHC	Male	III,IV	−0.667	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

Exploration

Same gene, other analysis: MIR99AHG RNA expression & survival · all MIR99AHG data types