Across TCGA pan-cancer cohorts, MIR99A RNA is linked to patient survival in 8 of 34 cancer types, making it the most broadly survival-associated MIR99A data layer.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MIR99A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MIR99A expression acts as an unfavorable survival marker, although some lineages such as OV and SARC show a favorable association.
HNSC, SKCM, and THCA are the cancer types where MIR99A RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.