Across TCGA pan-cancer cohorts, MIR7849 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR7849’s most consistent transcriptional readouts.
The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where MIR7849 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR7849 is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.
LIHC and LUAD are the cancer types where MIR7849 tumor–normal differential expression is most reproducible.