MIR6859-2

Across TCGA pan-cancer cohorts, MIR6859-2 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MIR6859-2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where MIR6859-2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR6859-2 is over-expressed in tumor, although a few such as BRCA and COAD show the opposite, repressed pattern.

LUSC, BRCA, and LIHC are the cancer types where MIR6859-2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR6859-2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	II,III,IV	+0.360	.006	4	view →
BRCA	Female	II,III,IV	−0.184	.005	4	view →
LIHC	All	II,III,IV	+0.312	.020	3	view →
COAD	All	III,IV	−0.452	.023	1	view →
KICH	All	II,III,IV	+0.295	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

MIR6859-2–LUSC

Open the LUSC breakdown →