Q-omics provides the consensus-scored MIR646HG profile across patient tissues and cancer cell-line models. MIR646HG expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in LGG. Among the 18 cancer types available for tumor–normal comparison, MIR646HG is differentially expressed in 10, with the highest sampling consensus in COAD. Additionally, MIR646HG RNA expression shows 14,233 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight LGG, COAD, and THYM as cancer lineages where MIR646HG shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MIR646HG — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MIR646HG survival associations across molecular data types. MIR646HG RNA expression shows survival associations in the most cancer types (23). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MIR646HG RNA expression–survival associations across cancer types. High MIR646HG expression shows unfavorable associations in LGG, KICH and CHOL, but favorable associations in LUAD, THYM and ESCA. The LGG Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LGG as the clearest survival context for MIR646HG RNA expression.
This table summarizes MIR646HG tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for MIR646HG. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MIR646HG shows lower tumor expression in COAD, UCEC and BRCA and higher tumor expression in BLCA, LUAD and THCA. The COAD box plot shows higher MIR646HG RNA expression in normal versus tumor tissue (log2 FC = −0.125, t-test p < 0.001).
This table shows molecular features associated with MIR646HG in patient tissues and cancer cell lines. In patient samples, MIR646HG shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
