Across TCGA patient cohorts, MIR646 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible MIR646-associated genes across cancer lineages are HMGN1P9, MIR5787, and MIR8089. Each is linked with MIR646 in more than 1 cancer types. Because this analysis shows association rather than direction, both MIR646-to-partner and partner-to-MIR646 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIR646→partner) and Y-score (partner→MIR646) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HMGN1P9 →	+0.111	+4.680	<.001	.007	3	1
SKCM	MIR5787 →	+0.772	+6.098	<.001	<.001	3	1
SKCM	MIR8089 →	+0.335	+4.680	<.001	.007	3	1
SKCM	CSTP2 →	+0.184	+6.021	<.001	<.001	3	1
SKCM	RPSAP64 →	+0.131	+4.594	<.001	.008	3	1
SKCM	CICP6 →	+0.021	+4.513	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

MIR646 survival (RNA) · tumor vs normal (RNA) · all MIR646 data types