Across TCGA pan-cancer cohorts, MIR589 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of MIR589’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MIR589 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR589 is over-expressed in tumor.
HNSC, COAD, and LIHC are the cancer types where MIR589 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR589 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.