Across TCGA pan-cancer cohorts, MIR550A3 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of MIR550A3’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where MIR550A3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR550A3 is over-expressed in tumor.
KIRP are the cancer types where MIR550A3 tumor–normal differential expression is most reproducible.