Across TCGA pan-cancer cohorts, MIR548O RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MIR548O’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MIR548O RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR548O is over-expressed in tumor, although a few such as READ and COAD show the opposite, repressed pattern.
KIRC, READ, and COAD are the cancer types where MIR548O tumor–normal differential expression is most reproducible.