Across TCGA pan-cancer cohorts, MIR548AG2 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR548AG2’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MIR548AG2 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR548AG2 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
KIRC and KICH are the cancer types where MIR548AG2 tumor–normal differential expression is most reproducible.