Q-omics provides the consensus-scored MIR543 profile across patient tissues and cancer cell-line models. MIR543 expression is associated with patient survival in 11 of 34 cancer types, with the highest sampling consensus in LIHC. Among the 18 cancer types available for tumor–normal comparison, MIR543 is differentially expressed in 1, with the highest sampling consensus in HNSC. Additionally, MIR543 RNA expression shows 7,184 significant gene co-expression associations, with the highest sampling consensus in BRCA. Together, these results highlight LIHC, HNSC, and BRCA as cancer lineages where MIR543 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MIR543 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MIR543 survival associations across molecular data types. MIR543 RNA expression shows survival associations in the most cancer types (11), followed by mutation status (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MIR543 RNA expression–survival associations across cancer types. High MIR543 expression shows unfavorable associations in LIHC, BLCA, KIRC, BRCA, UCEC and CESC. The LIHC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LIHC as the clearest survival context for MIR543 RNA expression.
This table summarizes MIR543 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 1. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for MIR543. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MIR543 shows higher tumor expression in HNSC. The HNSC box plot shows higher MIR543 RNA expression in tumor versus normal tissue (log2 FC = +0.089, t-test p = .034).
This table shows molecular features associated with MIR543 in patient tissues and cancer cell lines. In patient samples, MIR543 shows the broadest associations at the RNA and protein expression levels, with BRCA recurring as the lineage with the largest associated feature set.
