Across TCGA pan-cancer cohorts, MIR520C RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of MIR520C’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where MIR520C RNA is repressed in tumor relative to normal tissue. In most cancer types MIR520C is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA are the cancer types where MIR520C tumor–normal differential expression is most reproducible.