Across TCGA pan-cancer cohorts, MIR508 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR508’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MIR508 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR508 is over-expressed in tumor.
KIRC and KIRP are the cancer types where MIR508 tumor–normal differential expression is most reproducible.