MIR486-1

Across TCGA pan-cancer cohorts, MIR486-1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated MIR486-1 data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MIR486-1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MIR486-1 expression acts as an unfavorable survival marker, although some lineages such as LGG and HNSC show a favorable association.

LUAD, TGCT, and ESCA are the cancer types where MIR486-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	IV	0.302	0.794	<.001	69	view →
TGCT	OS	Tertile	All	0.936	1.000	.011	42	view →
ESCA	OS	Tertile	IV	0.127	0.571	.003	36	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	36	view →
LGG	DFS	Quartile	All	0.892	0.765	<.001	34	view →
BLCA	OS	Tertile	IV	0.252	0.483	.004	33	view →
THCA	OS	Tertile	All	0.307	0.957	<.001	33	view →
HNSC	DFS	Tertile	IV	0.538	0.253	.002	30	view →
UVM	OS	Tertile	All	0.292	0.674	.035	24	view →
STAD	OS	Quartile	IV	0.125	0.672	.001	21	view →
UCS	DFS	Tertile	IV	0.996	0.570	.039	18	view →
MESO	OS	Tertile	IV	0.077	0.592	.019	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

MIR486-1–LUAD (DFS)

Open the LUAD breakdown →