MIR486-1

Across TCGA pan-cancer cohorts, MIR486-1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MIR486-1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MIR486-1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR486-1 is over-expressed in tumor.

KIRC, PAAD, and LUAD are the cancer types where MIR486-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR486-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	III,IV	+0.221	<.001	7	view →
PAAD	Male	All	+1.380	.010	2	view →
LUAD	Female	All	+0.306	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

MIR486-1–KIRC

Open the KIRC breakdown →