Across TCGA pan-cancer cohorts, MIR4511 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MIR4511’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where MIR4511 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR4511 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.
THCA, BRCA, and LUSC are the cancer types where MIR4511 tumor–normal differential expression is most reproducible.