Across TCGA pan-cancer cohorts, MIR4504 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR4504’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where MIR4504 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR4504 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA and BRCA are the cancer types where MIR4504 tumor–normal differential expression is most reproducible.