MIR4453HG

Across TCGA pan-cancer cohorts, MIR4453HG RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated MIR4453HG data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher MIR4453HG RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MIR4453HG expression acts as an unfavorable survival marker, although some lineages such as UCS and READ show a favorable association.

UCS, READ, and MESO are the cancer types where MIR4453HG RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Quartile	II,III,IV	0.596	0.164	.001	88	view →
READ	OS	Median	II,III,IV	0.811	0.315	<.001	58	view →
MESO	DFS	Median	All	0.213	0.631	.001	30	view →
UVM	DFS	Quartile	III,IV	0.275	0.848	.007	23	view →
BRCA	DFS	Quartile	III,IV	0.945	0.783	.013	22	view →
LIHC	DFS	Quartile	All	0.240	0.549	.001	22	view →
BLCA	OS	Quartile	All	0.696	0.522	.001	21	view →
ACC	OS	Quartile	IV	0.817	0.306	.006	21	view →
PAAD	DFS	Quartile	All	0.431	0.175	.001	19	view →
SKCM	DFS	Quartile	All	0.651	0.498	.004	15	view →
HNSC	DFS	Median	IV	0.721	0.560	.002	15	view →
GBM	DFS	Quartile	All	0.442	0.192	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

MIR4453HG–UCS (DFS)

Open the UCS breakdown →