MIR4453HG

Across TCGA pan-cancer cohorts, MIR4453HG RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of MIR4453HG’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where MIR4453HG RNA is repressed in tumor relative to normal tissue. In most cancer types MIR4453HG is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, LIHC, and KIRC are the cancer types where MIR4453HG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR4453HG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−0.930	<.001	10	view →
LIHC	Female	II,III,IV	+0.689	<.001	9	view →
KIRC	Male	II,III,IV	−0.785	<.001	8	view →
HNSC	All	III,IV	+0.474	.006	8	view →
COAD	Male	All	+0.657	<.001	7	view →
BRCA	Female	All	−0.311	.001	6	view →
CHOL	All	All	+1.357	<.001	5	view →
STAD	All	All	+0.465	.007	5	view →
KICH	All	All	−0.929	<.001	4	view →
KIRP	Male	All	−0.699	<.001	3	view →
LUSC	All	All	+0.330	.002	3	view →
PAAD	Male	All	+0.555	.034	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

MIR4453HG–THCA

Open the THCA breakdown →