MIR4446

Across TCGA pan-cancer cohorts, MIR4446 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated MIR4446 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MIR4446 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MIR4446 expression acts as an unfavorable survival marker, although some lineages such as OV and LUAD show a favorable association.

KIRC, OV, and LIHC are the cancer types where MIR4446 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	IV	0.147	0.643	<.001	102	view →
OV	DFS	Tertile	All	0.570	0.365	.008	90	view →
LIHC	OS	Tertile	II,III,IV	0.117	0.617	.015	45	view →
ESCA	OS	Tertile	IV	0.135	0.568	.031	36	view →
LUAD	DFS	Tertile	All	0.832	0.652	.021	30	view →
THYM	OS	Tertile	III,IV	0.212	0.953	.009	27	view →
SKCM	OS	Tertile	III,IV	0.216	0.697	.022	18	view →
TGCT	OS	Tertile	All	0.694	0.968	.002	18	view →
PRAD	DFS	Tertile	All	0.981	0.926	.048	6	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

MIR4446–KIRC (DFS)

Open the KIRC breakdown →