MIR4446

Across TCGA pan-cancer cohorts, MIR4446 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MIR4446’s most consistent transcriptional readouts.

The strongest signal is observed in rectum adenocarcinoma (READ), where MIR4446 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR4446 is over-expressed in tumor, although a few such as READ and COAD show the opposite, repressed pattern.

READ, COAD, and KIRC are the cancer types where MIR4446 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR4446 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
READ	All	III,IV	−0.925	.017	3	view →
COAD	Female	II,III,IV	−0.268	.022	3	view →
KIRC	Male	All	+0.063	.042	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

MIR4446–READ

Open the READ breakdown →