Across TCGA pan-cancer cohorts, MIR4435-1 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of MIR4435-1’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where MIR4435-1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR4435-1 is over-expressed in tumor.
THCA are the cancer types where MIR4435-1 tumor–normal differential expression is most reproducible.