Across TCGA pan-cancer cohorts, MIR4424 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR4424’s most consistent transcriptional readouts.
The strongest signal is observed in stomach adenocarcinoma (STAD), where MIR4424 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR4424 is over-expressed in tumor, although a few such as STAD and KIRP show the opposite, repressed pattern.
STAD and KIRP are the cancer types where MIR4424 tumor–normal differential expression is most reproducible.