MIR4257

Across TCGA pan-cancer cohorts, MIR4257 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated MIR4257 data layer.

The strongest signal is observed in thyroid carcinoma (THCA), where higher MIR4257 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MIR4257 expression acts as an unfavorable survival marker, although some lineages such as MESO and ESCA show a favorable association.

THCA, UVM, and OV are the cancer types where MIR4257 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Tertile	II,III,IV	0.826	0.943	<.001	105	view →
UVM	DFS	Tertile	III,IV	0.374	0.812	<.001	99	view →
OV	OS	Quartile	III,IV	0.761	0.865	.005	74	view →
LGG	DFS	Median	All	0.332	0.471	<.001	53	view →
BLCA	DFS	Tertile	III,IV	0.192	0.430	.001	43	view →
MESO	DFS	Tertile	III,IV	0.571	0.306	.004	38	view →
ESCA	OS	Tertile	III,IV	0.738	0.424	.001	27	view →
CHOL	DFS	Median	II,III,IV	0.145	0.567	.002	24	view →
COAD	DFS	Quartile	All	0.244	0.562	.002	24	view →
UCS	OS	Tertile	IV	1.000	0.293	.035	18	view →
TGCT	DFS	Quartile	All	0.969	0.590	.002	12	view →
SKCM	DFS	Tertile	All	0.802	0.698	.011	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

MIR4257–THCA (DFS)

Open the THCA breakdown →