Across TCGA pan-cancer cohorts, MIR345 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MIR345’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MIR345 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR345 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and LUSC are the cancer types where MIR345 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR345 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.298	<.001	11	view →
THCA	All	IV	−1.847	.006	7	view →
LUSC	All	All	+0.188	.004	3	view →
KIRP	All	All	−0.357	.017	2	view →
KICH	Female	All	−0.331	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: MIR345 RNA expression & survival · all MIR345 data types