Across TCGA pan-cancer cohorts, MIR3180-4 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR3180-4’s most consistent transcriptional readouts.
The strongest signal is observed in esophageal carcinoma (ESCA), where MIR3180-4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR3180-4 is over-expressed in tumor.
ESCA and STAD are the cancer types where MIR3180-4 tumor–normal differential expression is most reproducible.