Across TCGA pan-cancer cohorts, MIR302C RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MIR302C’s most consistent transcriptional readouts.
The strongest signal is observed in rectum adenocarcinoma (READ), where MIR302C RNA is repressed in tumor relative to normal tissue. In most cancer types MIR302C is over-expressed in tumor, although a few such as READ show the opposite, repressed pattern.
READ, KIRC, and ESCA are the cancer types where MIR302C tumor–normal differential expression is most reproducible.