Across TCGA pan-cancer cohorts, MIR208B RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of MIR208B’s most consistent transcriptional readouts.
The strongest signal is observed in prostate adenocarcinoma (PRAD), where MIR208B RNA is repressed in tumor relative to normal tissue. In most cancer types MIR208B is over-expressed in tumor, although a few such as PRAD show the opposite, repressed pattern.
PRAD are the cancer types where MIR208B tumor–normal differential expression is most reproducible.