Across TCGA pan-cancer cohorts, MIR200B RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of MIR200B’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MIR200B RNA is repressed in tumor relative to normal tissue. In most cancer types MIR200B is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.
KIRC, COAD, and KIRP are the cancer types where MIR200B tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR200B RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.