Across TCGA pan-cancer cohorts, MIR185 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR185’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where MIR185 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR185 is over-expressed in tumor.
KICH and BRCA are the cancer types where MIR185 tumor–normal differential expression is most reproducible.