Across TCGA patient cohorts, MIR154 mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible MIR154-associated genes across cancer lineages are H2AB3, C8orf87, and SSTR5. Each is linked with MIR154 in more than 1 cancer types. Because this analysis shows association rather than direction, both MIR154-to-partner and partner-to-MIR154 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIR154→partner) and Y-score (partner→MIR154) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	H2AB3 →	+0.076	+7.232	<.001	<.001	3	1
SKCM	C8orf87 →	+0.077	+3.913	.007	.006	3	1
UCEC	SSTR5 →	+1.002	+3.506	<.001	.007	3	1
SKCM	MTCO3P41 →	+0.103	+4.495	<.001	.007	3	1
SKCM	RPL23AP33 →	+0.059	+5.634	<.001	.001	3	1
SKCM	RN7SL743P →	+0.150	+4.163	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Exploration

MIR154 survival (RNA) · tumor vs normal (RNA) · all MIR154 data types