Across TCGA pan-cancer cohorts, MIR1255A RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of MIR1255A’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MIR1255A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR1255A is over-expressed in tumor, although a few such as BRCA and LUAD show the opposite, repressed pattern.
KIRC, BRCA, and PAAD are the cancer types where MIR1255A tumor–normal differential expression is most reproducible.