MIR124-1HG

Across TCGA pan-cancer cohorts, MIR124-1HG RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated MIR124-1HG data layer.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher MIR124-1HG RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MIR124-1HG expression acts as an unfavorable survival marker, although some lineages such as LGG and BLCA show a favorable association.

DLBC, LGG, and ACC are the cancer types where MIR124-1HG RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Quartile	III,IV	0.080	0.984	.001	67	view →
LGG	OS	Median	All	0.538	0.376	<.001	45	view →
ACC	OS	Tertile	III,IV	0.311	0.789	.002	39	view →
UVM	OS	Quartile	All	0.638	0.967	.001	37	view →
BLCA	OS	Tertile	II,III,IV	0.722	0.579	.013	33	view →
LUAD	OS	Tertile	IV	0.114	0.560	.038	30	view →
UCS	OS	Quartile	All	0.199	0.444	.016	26	view →
CESC	OS	Tertile	III,IV	0.909	0.584	.027	24	view →
PAAD	DFS	Tertile	III,IV	0.118	0.734	.014	18	view →
COAD	OS	Tertile	IV	0.064	0.678	<.001	18	view →
PCPG	DFS	Median	All	1.000	0.688	.003	17	view →
ESCA	DFS	Median	All	0.469	0.333	.030	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

MIR124-1HG–DLBC (DFS)

Open the DLBC breakdown →