Across TCGA pan-cancer cohorts, MIR107 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR107’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where MIR107 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR107 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA and PRAD are the cancer types where MIR107 tumor–normal differential expression is most reproducible.