MIOX

Across TCGA patient cohorts, MIOX mutation is significantly associated with the RNA expression of many other genes, with 757 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIOX-associated genes across cancer lineages are RNASE11, OR5L2, and E2F1. Each is linked with MIOX in more than 1 cancer types. Because this analysis shows association rather than direction, both MIOX-to-partner and partner-to-MIOX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNASE11 grouped by MIOX-low versus MIOX-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIOX→partner) and Y-score (partner→MIOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNASE11 →	+0.024	+7.930	<.001	.008	3	2
LUAD	OR5L2 →	+0.034	+7.930	<.001	.008	3	2
UCEC	E2F1 →	+0.986	+3.700	<.001	.001	3	2
UCEC	ACD →	+0.557	+3.343	<.001	.005	3	2
UCEC	PLEKHJ1 →	+0.682	+3.732	<.001	<.001	3	2
UCEC	NEIL3 →	+0.624	+3.343	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 757 associations by consensus.

RNASE11 by MIOX expression — LUAD

Explore this box plot interactively →