MIOX

Across TCGA pan-cancer cohorts, MIOX RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of MIOX’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where MIOX RNA is repressed in tumor relative to normal tissue. In most cancer types MIOX is over-expressed in tumor, although a few such as KIRP and THCA show the opposite, repressed pattern.

KIRP, THCA, and COAD are the cancer types where MIOX tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIOX RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	−4.996	<.001	11	view →
THCA	Male	III,IV	−3.937	<.001	11	view →
COAD	All	II,III,IV	+0.633	<.001	10	view →
KICH	Male	II,III,IV	−6.754	<.001	9	view →
HNSC	Male	All	+0.602	<.001	8	view →
LUAD	All	II,III,IV	+0.874	<.001	7	view →
BLCA	All	All	+0.402	.001	6	view →
STAD	All	All	+0.742	.001	5	view →
KIRC	Male	All	−1.833	<.001	4	view →
LUSC	Male	II,III,IV	+0.619	<.001	4	view →
CHOL	All	All	+0.512	<.001	4	view →
LIHC	All	All	+0.449	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

MIOX–KIRP

Open the KIRP breakdown →