MIOX

Across TCGA patient cohorts, MIOX mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIOX-associated genes across cancer lineages are Akt_pT308, S6_pS240_S244, and Annexin_VII. Each is linked with MIOX in more than 1 cancer types. Because this analysis shows association rather than direction, both MIOX-to-partner and partner-to-MIOX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by MIOX-low versus MIOX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIOX→partner) and Y-score (partner→MIOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.655	+2.321	.038	.035	3	1
UCEC	S6_pS240_S244 →	+0.514	+2.321	.011	.035	3	1
UCEC	Annexin_VII →	-0.153	-3.459	.028	.005	3	1
UCEC	CDK1_pY15 →	+0.260	+2.829	.012	.035	3	1
UCEC	FoxM1 →	+0.270	+3.009	.037	.019	2	1
UCEC	Cyclin-B1 →	+0.776	+3.459	.005	.005	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Akt_pT308 by MIOX expression — UCEC

Explore this box plot interactively →