MIOX

Across TCGA cell cohorts, MIOX mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MIOX-associated genes across cancer lineages are CGB2, DACT2, and VWC2L. Each is linked with MIOX in more than 1 cancer types. Because this analysis shows association rather than direction, both MIOX-to-partner and partner-to-MIOX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CGB2 grouped by MIOX-low versus MIOX-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIOX→partner) and Y-score (partner→MIOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CGB2 →	+0.676	+3.234	<.001	.008	3	1
BLOOD_Leukemia	DACT2 →	+0.012	+3.623	.004	.007	3	1
BLOOD_Leukemia	VWC2L →	+0.009	+3.339	<.001	.006	3	1
BLOOD_Leukemia	PROP1 →	+0.020	+3.289	.001	.009	3	1
BLOOD_Leukemia	AQP12B →	+0.255	+3.926	<.001	.003	3	1
BLOOD_Leukemia	MAP1LC3C →	+0.035	+3.771	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

CGB2 by MIOX expression — BLOOD_Leukemia

Explore this box plot interactively →