MIOS

Across TCGA patient cohorts, MIOS mutation is significantly associated with the RNA expression of many other genes, with 3,419 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIOS-associated genes across cancer lineages are CDCA3, KIF20A, and NUSAP1. Each is linked with MIOS in more than 2 cancer types. Because this analysis shows association rather than direction, both MIOS-to-partner and partner-to-MIOS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDCA3 grouped by MIOS-low versus MIOS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIOS→partner) and Y-score (partner→MIOS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDCA3 →	+0.512	+2.032	<.001	<.001	3	3
UCEC	KIF20A →	+0.662	+1.765	<.001	<.001	3	3
UCEC	NUSAP1 →	+0.824	+2.584	<.001	<.001	3	3
UCEC	TIMM21 →	+0.494	+2.283	<.001	<.001	3	3
UCEC	TIGAR →	+0.604	+2.042	<.001	<.001	3	3
LUSC	RNU6-23P →	+0.111	+3.121	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,419 associations by consensus.

CDCA3 by MIOS expression — UCEC

Explore this box plot interactively →