MINK1

Across TCGA patient cohorts, MINK1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MINK1-associated genes across cancer lineages are ASNS, A-Raf_pS299, and GAPDH. Each is linked with MINK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MINK1-to-partner and partner-to-MINK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by MINK1-low versus MINK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MINK1→partner) and Y-score (partner→MINK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.245	+1.157	.014	.014	3	3
UCEC	A-Raf_pS299 →	-0.089	-1.514	.007	.014	3	2
UCEC	GAPDH →	+0.392	+1.736	.008	.005	3	2
UCEC	p62 Lck ligand →	+0.329	+2.874	<.001	<.001	3	2
UCEC	TFRC →	+0.323	+1.765	.029	.011	3	2
COAD	Cyclin-B1 →	+0.716	+2.815	.016	.036	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ASNS by MINK1 expression — UCEC

Explore this box plot interactively →