Across TCGA pan-cancer cohorts, MINDY4B RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of MINDY4B’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MINDY4B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MINDY4B is over-expressed in tumor, although a few such as UCEC and PRAD show the opposite, repressed pattern.
HNSC, KIRC, and BRCA are the cancer types where MINDY4B tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MINDY4B RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.