MINDY4

Across TCGA patient cohorts, MINDY4 mutation is significantly associated with the RNA expression of many other genes, with 2,895 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MINDY4-associated genes across cancer lineages are RPS10P21, TP53TG3GP, and C18orf54. Each is linked with MINDY4 in more than 3 cancer types. Because this analysis shows association rather than direction, both MINDY4-to-partner and partner-to-MINDY4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS10P21 grouped by MINDY4-low versus MINDY4-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MINDY4→partner) and Y-score (partner→MINDY4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RPS10P21 →	+0.257	+5.095	<.001	<.001	3	4
GBM	TP53TG3GP →	+0.889	+6.189	<.001	.001	3	3
UCEC	C18orf54 →	+0.740	+3.058	<.001	<.001	3	3
UCEC	TXNL1 →	+0.345	+2.764	.004	.002	3	3
UCEC	LIN7B →	+0.465	+2.947	<.001	<.001	3	3
LUSC	RNA5SP369 →	+0.087	+4.158	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,895 associations by consensus.

RPS10P21 by MINDY4 expression — BLCA

Explore this box plot interactively →