MINCR

Across TCGA pan-cancer cohorts, MINCR RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of MINCR’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MINCR RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MINCR is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

COAD, LIHC, and READ are the cancer types where MINCR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MINCR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+1.488	<.001	11	view →
LIHC	Male	II,III,IV	+1.944	<.001	8	view →
READ	All	All	+1.063	.006	7	view →
THCA	Male	All	−0.791	<.001	7	view →
KIRC	Male	All	−0.682	<.001	7	view →
KICH	Female	All	−1.175	<.001	6	view →
STAD	All	All	+0.750	<.001	6	view →
LUSC	All	II,III,IV	+0.993	<.001	5	view →
BLCA	Female	III,IV	+0.977	.028	5	view →
CHOL	All	All	+1.558	<.001	3	view →
BRCA	All	IV	−0.940	.012	2	view →
LUAD	All	All	+0.327	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

MINCR–COAD

Open the COAD breakdown →