MIGA2

Across TCGA cell cohorts, MIGA2 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MIGA2-associated genes across cancer lineages are TFDP3, C14orf180, and NEXMIF. Each is linked with MIGA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MIGA2-to-partner and partner-to-MIGA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFDP3 grouped by MIGA2-low versus MIGA2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIGA2→partner) and Y-score (partner→MIGA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TFDP3 →	+0.029	+4.196	<.001	.002	3	1
LARGE_INTESTINE	C14orf180 →	+0.124	+4.155	<.001	.003	3	1
LARGE_INTESTINE	NEXMIF →	+0.319	+4.196	<.001	.002	3	1
BLOOD_Leukemia	SLC22A11 →	+0.269	+3.584	.002	.004	3	1
BLOOD_Leukemia	ADIG →	+0.011	+3.984	<.001	.006	3	1
BLOOD_Leukemia	A3GALT2 →	+0.028	+2.870	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

TFDP3 by MIGA2 expression — LARGE_INTESTINE

Explore this box plot interactively →