MIF

Across TCGA patient cohorts, MIF RNA expression is significantly associated with the go_rna of many other GO terms, with 7,163 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible MIF-associated GO terms across cancer lineages are Post-Golgi vesicle-mediated transport, tRNA thio-modification, and Regulation of vacuole organization. Each is linked with MIF in more than 25 cancer types. Because this analysis shows association rather than direction, both MIF-to-partner and partner-to-MIF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Post-Golgi vesicle-mediated transport grouped by MIF-low versus MIF-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MIF→partner) and Y-score (partner→MIF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Post-Golgi vesicle-mediated transport →	-0.063	-1.334	<.001	<.001	3	26
SCLC	tRNA thio-modification →	+0.137	+1.060	<.001	<.001	2	26
THYM	Regulation of vacuole organization →	-0.060	-0.617	<.001	<.001	3	25
THYM	Phosphatidylinositol-3-phosphate biosynthetic process →	-0.078	-0.710	<.001	<.001	3	25
TGCT	Regulation of focal adhesion disassembly →	-0.089	-0.791	<.001	<.001	3	24
DLBC	Peptidyl-serine autophosphorylation →	-0.072	-0.946	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,163 associations by consensus.

Post-Golgi vesicle-mediated transport by MIF expression — ESCA

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