MIF

Across TCGA pan-cancer cohorts, MIF RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MIF’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MIF RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIF is over-expressed in tumor.

HNSC, KIRC, and COAD are the cancer types where MIF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.577	<.001	12	view →
KIRC	Female	IV	+1.573	<.001	12	view →
COAD	Female	All	+1.950	<.001	11	view →
BLCA	Male	All	+1.367	<.001	11	view →
LUSC	Male	II,III,IV	+2.018	<.001	9	view →
LIHC	All	II,III,IV	+1.255	<.001	8	view →
READ	All	All	+1.202	.001	7	view →
BRCA	All	III,IV	+1.336	<.001	6	view →
LUAD	Female	III,IV	+1.335	<.001	6	view →
KIRP	All	II,III,IV	+0.738	.001	6	view →
STAD	All	All	+0.594	.007	4	view →
CHOL	Male	All	+2.168	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MIF–HNSC

Open the HNSC breakdown →