MIF

Across TCGA patient cohorts, MIF mutation is significantly associated with the RNA expression of many other genes, with 102 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIF-associated genes across cancer lineages are MIR920, RPL23AP4, and LINC01069. Each is linked with MIF in more than 1 cancer types. Because this analysis shows association rather than direction, both MIF-to-partner and partner-to-MIF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR920 grouped by MIF-low versus MIF-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIF→partner) and Y-score (partner→MIF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR920 →	+0.505	+5.539	<.001	.004	3	2
UCEC	RPL23AP4 →	+0.103	+3.717	<.001	<.001	3	2
CESC	LINC01069 →	+0.078	+6.837	<.001	<.001	3	1
CESC	LINC02353 →	+0.076	+5.669	<.001	.003	3	1
CESC	HMGB1P46 →	+0.249	+5.103	<.001	.008	3	1
CESC	HSPD1P13 →	+0.025	+6.342	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 102 associations by consensus.

MIR920 by MIF expression — CESC

Explore this box plot interactively →