MIF

Across TCGA cell cohorts, MIF RNA expression is significantly associated with the go_rna of many other GO terms, with 3,130 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MIF-associated GO terms across cancer lineages are Negative regulation of macrophage chemotaxis, Protein localization to microtubule plus-end, and Protein localization to microtubule end. Each is linked with MIF in more than 14 cancer types. Because this analysis shows association rather than direction, both MIF-to-partner and partner-to-MIF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of macrophage chemotaxis grouped by MIF-low versus MIF-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MIF→partner) and Y-score (partner→MIF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of macrophage chemotaxis →	+0.527	+2.454	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Protein localization to microtubule plus-end →	+0.225	+1.554	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Protein localization to microtubule end →	+0.225	+1.554	<.001	<.001	3	14
SOFT_TISSUE	Negative regulation of macrophage migration →	+0.482	+2.386	.001	<.001	3	13
SKIN	Protein to membrane docking →	+0.081	+1.218	<.001	<.001	3	10
BONE	Cytoplasm protein quality control by the ubiquitin-proteasome system →	+0.163	+1.259	<.001	<.001	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,130 associations by consensus.

Negative regulation of macrophage chemotaxis by MIF expression — SOFT_TISSUE

Explore this box plot interactively →