MIEF1

Across TCGA cell cohorts, MIEF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,073 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MIEF1-associated GO terms across cancer lineages are Negative regulation of chromosome condensation, Positive regulation of mitochondrial fusion, and Positive regulation of T-helper 17 cell lineage commitment. Each is linked with MIEF1 in more than 19 cancer types. Because this analysis shows association rather than direction, both MIEF1-to-partner and partner-to-MIEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chromosome condensation grouped by MIEF1-low versus MIEF1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MIEF1→partner) and Y-score (partner→MIEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of chromosome condensation →	+0.176	+0.661	<.001	<.001	3	20
URINARY_TRACT	Positive regulation of mitochondrial fusion →	+0.223	+1.077	<.001	<.001	3	18
LIVER	Positive regulation of T-helper 17 cell lineage commitment →	+0.204	+0.980	<.001	.002	2	18
OVARY	Positive regulation of cell fate commitment →	+0.217	+0.637	<.001	.001	3	15
BLOOD_Lymphoma	P-body assembly →	+0.107	+1.002	<.001	<.001	3	15
BONE	Ribosomal large subunit assembly →	+0.118	+0.633	.002	.003	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,073 associations by consensus.

Negative regulation of chromosome condensation by MIEF1 expression — LUNG_NSCLC_LUSC

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